TRANSFORMATION OF 5-ALPHA-H-PREGN-16-EN-3-BETA-OL-20-ONE INTO N-4-ENE-9-ALPHA,16-ALPHA,17-ALPHA-TRIOL-3,20-DIONE 16,17-ACETONIDE

Authors
TURUTA AM VOISHVILLO NE KAMERNITSKII AV DZHLANTIASHVILI NV KOROBOV AA
Citation
Am. Turuta et al., TRANSFORMATION OF 5-ALPHA-H-PREGN-16-EN-3-BETA-OL-20-ONE INTO N-4-ENE-9-ALPHA,16-ALPHA,17-ALPHA-TRIOL-3,20-DIONE 16,17-ACETONIDE, Bulletin of the Russian Academy of Sciences, Division of Chemical Sciences, 41(8), 1992, pp. 1482-1484
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Russian Academy of Sciences, Division of Chemical Sciences → ACNP
ISSN journal
10635211
Volume
41
Issue
8
Year of publication
1992
Part
2
Pages
1482 - 1484
Database
ISI
SICI code
1063-5211(1992)41:8<1482:TO5IN>2.0.ZU;2-I
Abstract
A preparative method was proposed for the preparation of regn-4-ene-9a lpha,16alpha,17alpha-triol-3,20-dione 16alpha,17alpha-acetonide (2) fr om 5alpha-H-pregn-16-en-3beta-ol-20-one (1). The kev stage in the prop osed sequence of the reactions is the microbiological 9alpha-hydroxyla tion and introduction of the 4-en-3-one grouping into the molecule of 1 by R- and S-dissociative forms of the Rhodococcus sp. strain.