Aoc. Jorge et al., EFFECT OF SIALOADENECTOMY ON THE CARRIAGE OF CANDIDA-ALBICANS IN THE MOUTHS OF RATS, Journal of oral pathology & medicine, 22(3), 1993, pp. 138-140
Xerostomia provoked in rats by surgical removal of the major salivary
glands significantly increased oral carriage of Candida albicans. Five
weeks after 3 oral inoculations of 10(8) CFU, C albicans were found i
n the mouths in 50% of normal animals but after 8 weeks in none. In xe
rostomic rats, 100% had oral C. albicans after 5 weeks and after 18 we
eks, 66.6% still harboured yeasts. Over the whole experimental period
the amount of C. albicans was greater in the mouths of sialoadenectomi
zed than in normal rats.