PROPHYLACTIC APPLICATION OF PROPIONIBACTERIUM-AVIDUM KP-40 IN SWINE WITH ACUTE EXPERIMENTAL INFECTIONS .1. VIRAL-INFECTIONS - AUJESZKYS DISEASE AND CLASSICAL SWINE FEVER

The usefulness of the prophylactic application of Propionibacterium av idum KP-40 (PA), a potent stimulator of the macrophage-monocyte system and inducer of endogenous interferons, was demonstrated in swine infe cted experimentally with Aujeszky's disease or classical swine fever v iruses. Some of the infected animals were preimmunized with respective vaccines containing live, attenuated viruses. In vaccinated and non-v accinated swine infected with Aujeszky's disease virus, pretreatment w ith PA lowered the morbidity rate, shortened the period of fever and f astened the recovery. Infection with classical swine fever virus resul ted in 100 % mortality of PA-pretreated non-vaccinated swine, but the length survival of the animals was significantly longer (p < 0.05).