IMPAIRED FIBRINOLYTIC-ACTIVITY INDUCED BY INGESTION OF BUTTER - EFFECT OF INCREASED PLASMA-LIPIDS ON THE FIBRINOLYTIC-ACTIVITY

To investigate the effects of the increased plasma lipid level on fibr inolysis, we measured the levels of fibrinolytic components in seriall y obtained plasma samples from healthy volunteers after the intake of different amounts of butter. Plasma triglyceride level increased signi ficantly after butter intake compared to the control group. Eight hour s after the intake of 100g of butter, plasminogen activator inhibitor 1 (PAI-1) level in plasma was significantly higher and euglobulin clot lysis time was significantly prolonged compared to those of the contr ol group. There was no effect on plasma tissue plasminogen activator l evel. These results suggest that the temporary increase in plasma trig lyceride level induced high PAI-1 level, resulting in impaired fibrino lytic activity. The effect of temporary hyperlipidemia on platelet fun ction was also analyzed and revealed that the response of platelets to ADP and collagen was lower in the butter intake group compared to tho se of the control.