NMR-STUDIES ON PENICILLINS - HYDROGEN-BONDING, SELF-ASSOCIATION AND MICELLAR SOLUTIONS OF CLOXACILLIN NA-SALT IN D2O

Authors
KUPKA T DZIEGIELEWSKI JO PASTERNA G
Citation
T. Kupka et al., NMR-STUDIES ON PENICILLINS - HYDROGEN-BONDING, SELF-ASSOCIATION AND MICELLAR SOLUTIONS OF CLOXACILLIN NA-SALT IN D2O, Journal of pharmaceutical and biomedical analysis, 11(2), 1993, pp. 103-116
Citations number
45
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
11
Issue
2
Year of publication
1993
Pages
103 - 116
Database
ISI
SICI code
0731-7085(1993)11:2<103:NOP-HS>2.0.ZU;2-A
Abstract
Self-association and formation of micellar solutions of cloxacillin so dium salt (CLO-Na) dissolved in heavy water have been investigated by NMR spectroscopy. Concentration and temperature dependence of proton a nd carbon chemical shifts of cloxacillin-Na in D2O is presented and ce rtain H-1 and C-13 NMR line assignments have been substantiated.