We studied the effect of pressure patching in 27 medical students. Fou
rteen students had pressure patching in one eye (group 1) and 13 (grou
p 2) had light patching. The fellow eye of each volunteer remained unp
atched (group 3). Clinical signs and symptoms were scored and evaluate
d at the first and the following (after overnight) examinations. Befor
e patching no subject had any of the clinical signs or symptoms. After
the patch was removed in groups 1 and 2, all except one volunteer in
each group had clinical signs or symptoms, or both, whereas in group 3
, none had clinical signs or symptoms. Group 1 had greater scores for
clinical signs (P = .019) and for symptoms (P = .038) as compared to g
roup 2. In group 1, two participants did not complete the study period
(by removal of the patch) because of severe discomfort and three had
temporary irregularities in corneal surface with temporary decrease of
vision. We suggest that pressure patching may cause discomfort and ch
anges in visual acuity that are usually attributed to other reasons.