EOSINOPHIL GRANULE MAJOR BASIC-PROTEIN DEPOSITION IN CORNEAL ULCERS ASSOCIATED WITH VERNAL KERATOCONJUNCTIVITIS

Authors
TROCME SD KEPHART GM BOURNE WM BUCKLEY RJ GLEICH GJ
Citation
Sd. Trocme et al., EOSINOPHIL GRANULE MAJOR BASIC-PROTEIN DEPOSITION IN CORNEAL ULCERS ASSOCIATED WITH VERNAL KERATOCONJUNCTIVITIS, American journal of ophthalmology, 115(5), 1993, pp. 640-643
Citations number
22
Categorie Soggetti
Ophthalmology
Journal title
American journal of ophthalmology → ACNP
ISSN journal
00029394
Volume
115
Issue
5
Year of publication
1993
Pages
640 - 643
Database
ISI
SICI code
0002-9394(1993)115:5<640:EGMBDI>2.0.ZU;2-R
Abstract
An indirect immunofluorescence assay detected eosinophil granule major basic protein in the inflammatory debris covering deepithelialized co rnea in two patients with vernal keratoconjunctivitis. A slight degree of nonspecific fluorescence was present in the control autopsy cornea s. High concentrations of the eosinophil granule major basic protein i nhibit epithelial migration and protein synthesis, whereas low concent rations affect epithelial migration. The results suggest participation of eosinophil granule major basic protein in the ulcerative process.