Gallstone disease is an important clinical problem: approximately 10%
of all adults in the western population have gallstones. Most gallston
es, however, remain asymptomatic, and from various disciplines there i
s consensus that only symptomatic gallstones require therapy. Since th
e first gallbladder extirpation in 1882, cholecystectomy has been cons
idered the gold standard. Nowadays, this operation is performed laparo
scopically in most hospitals. Despite relatively low morbidity and mor
tality rates, a number of alternative therapies have been developed in
the past few years. These alternative treatment modalities are especi
ally indicated in high risk patients and in patients rejecting surgery
. In this review article, the currently available treatment modalities
are discussed.