LONG-TERM TREATMENT OF CHRONIC HEPATITIS-C WITH INTERFERON-ALFA-2B - DISAPPEARANCE OF HCV-RNA IN A PILOT-STUDY OF 8 HEMOPHILIA PATIENTS

Authors
BRESTERS D MAUSERBUNSCHOTEN EP CUYPERS HTM HAN JH JANSEN PLM CHAMULEAU RAFM HOUGHTON M REESINK HW
Citation
D. Bresters et al., LONG-TERM TREATMENT OF CHRONIC HEPATITIS-C WITH INTERFERON-ALFA-2B - DISAPPEARANCE OF HCV-RNA IN A PILOT-STUDY OF 8 HEMOPHILIA PATIENTS, Gut, 34(2), 1993, pp. 124-125
Citations number
2
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Gut → ACNP
ISSN journal
00175749
Volume
34
Issue
2
Year of publication
1993
Supplement
S
Pages
124 - 125
Database
ISI
SICI code
0017-5749(1993)34:2<124:LTOCHW>2.0.ZU;2-H
Abstract
This pilot study was designed to establish the effect of long term alp ha interferon treatment in haemophilia patients with chronic hepatitis C. Overall, three of eight (37.5%) patients showed a complete respons e, three of eight (37.5%) a transient response, and two of eight (25.0 %) no response. HCV-RNA detection by polymerase chain reaction was mor e sensitive in detecting relapse than alanine aminotransferase (ALT) a ctivity measurement, suggesting that current interferon schedules base d on the ALT response should be re-evaluated critically.