ALPHA-INTERFERON TREATMENT OF CHRONIC HEPATITIS-C IN BETA-THALASSEMIA

Authors
DIMARCO V LOIACONO O CAPRA M GRUTTA S CIACCIO C GERARDI C MAGGIO A RENDA D ALMASIO P PISA R CRAXI A
Citation
V. Dimarco et al., ALPHA-INTERFERON TREATMENT OF CHRONIC HEPATITIS-C IN BETA-THALASSEMIA, Gut, 34(2), 1993, pp. 142-143
Citations number
NO
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Gut → ACNP
ISSN journal
00175749
Volume
34
Issue
2
Year of publication
1993
Supplement
S
Pages
142 - 143
Database
ISI
SICI code
0017-5749(1993)34:2<142:ATOCHI>2.0.ZU;2-T
Abstract
In this open, pilot study, interferon (IFN) alpha-2b seemed effective in the treatment of hepatitis C virus (HCV) infection in patients with beta-thalassaemia. In seven of nine patients who completed the study alanine aminotransferase activities returned to normal, and a complete ly stable response 24 months after treatment was seen in five. Liver b iopsy specimen showed a clear reduction in portal, periportal, and lob ular necroinflammation in all five cases. Three patients stopped treat ment early because of side effects.