R. Heddle et al., INTEGRATION OF CANINE PROXIMAL GASTRIC, ANTRAL, PYLORIC, AND PROXIMALDUODENAL MOTILITY DURING FASTING AND AFTER A LIQUID MEAL, Digestive diseases and sciences, 38(5), 1993, pp. 856-869
The aim was to investigate the integration of proximal gastric, antral
, pyloric, and duodenal motility during fasting and after feeding. Usi
ng a proximal gastric barostat and a manometric assembly with an array
of side holes astride the gastroduodenal junction, the gastrointestin
al interdigestive migrating motor complex was detected in five of seve
n conscious fasting dogs. During phase III of the complex, which laste
d a mean +/- SEM of 13 +/- 0.5 min, 9.6 +/- 0.9 volume waves were pres
ent in the proximal stomach. The volume waves were coordinated with cl
usters of antral waves 64 +/- 11% of the time and with inhibition of d
uodenal waves 91 +/- 3% of the time. A 300-ml calorie-dense liquid mea
l abolished the complex and promptly increased proximal gastric volume
in five of six dogs. Volume waves were nearly completely suppressed,
while antral waves decreased from 24 +/- 3.0 waves/10 min to 10 +/- 2.
8 waves/10 min (P < 0.05) and isolated pyloric pressure waves increase
d from 7.2 +/- 2.8 waves/10 min to 22 +/- 3.3 waves/10 min (P < 0.005)
. In summary, proximal gastric motility was integrated with antral, py
loric, and duodenal motility under both fasting and fed conditions. Th
e integrated patterns likely account for the efficient clearance of in
digestible solids during fasting and the controlled emptying of nutrie
nts with feeding.