CORTISOL PRODUCTION BY ALDOSTERONE-PRODUCING ADENOMAS INVITRO

Citation
M. Stowasser et al., CORTISOL PRODUCTION BY ALDOSTERONE-PRODUCING ADENOMAS INVITRO, Clinical and experimental pharmacology and physiology, 20(5), 1993, pp. 292-295
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Physiology
ISSN journal
03051870
Volume
20
Issue
5
Year of publication
1993
Pages
292 - 295
Database
ISI
SICI code
0305-1870(1993)20:5<292:CPBAAI>2.0.ZU;2-P
Abstract
1. In vitro short-term production of cortisol by dispersed tumour and non-tumorous adrenal cortical cells was measured with and without adde d angiotensin II (AII) or adrenocorticotrophin (ACTH) in adrenals remo ved from five patients with primary aldosteronism. 2. Aldosterone-prod ucing adenomas (APA) were classified as angiotensin responsive (AII-R) or angiotensin unresponsive (AII-U) based on pre-operative behaviour in vivo. 3. Cortisol was produced by both tumour and cortex in vitro w ithout stimulation, and significantly more cortisol was generated by t he cortex. 4. Addition of AII significantly increased cortisol product ion by both tumour and cortex to an equal extent. 5. Addition of ACTH also significantly increased cortisol production by both tumour and co rtex, but tumours were more responsive than cortex. The response to AC TH exceeded the response to angiotensin in both tumour and cortex. 6. There was no obvious difference between AII-R and AII-U APA in terms o f cortisol production.