Thermoregulation and its impairment by anaesthesia and surgery has rec
ently been brought back into focus by researchers and clinicians. All
Volatile and IV anaesthetics, opioids, as well as spinal and epidural
anaesthesia increase the inter-threshold range of thermoregulation fro
m 0.2 degrees C to 4 degrees C between vasodilation and vasoconstricti
on. Thermoregulatory vasoconstriction and shivering occurs in anaesthe
tized patients at lower core temperatures than in awake subjects. Foll
owing induction of general or spinal/epidural anaesthesia,care tempera
ture decreases significantly due to internal redistribution of body he
at from the core thermal compartment to peripheral tissues. About 1 h
after induction of general anaesthesia and initial redistribution hypo
thermia, a real reduction in body heat occurs as heat loss exceeds met
abolic heat production. Heat loss is further increased due to low oper
ating room temperatures, evaporation from open body cavities,and cold
IV fluids. Peripheral thermoregulatory vasoconstriction is triggered b
y core temperatures between 33 degrees C and 35 degrees C,and is able
to slow heat loss. However body heat content continues to decrease eve
n though core temperatures remain nearly constant. During spinal or ep
idural anaesthesia thermoregulation remains intact in the unblocked bo
dy segments, leading to reduced real heat loss when compared to genera
l anaesthesia. Inadvertent hypothermia markedly decreases drug metabol
ism. Coagulation is impaired by cold-induced defects of platelet funct
ion. Hypothermia reduces neutrophil phagocytosis and oxidative killing
capacity, causing wound infections. Postoperative hypothermia represe
nts an unnecessary stress for the circulatory system, elevating plasma
catecholamines and leading to myocardial ischaemia and arrhythmias. T
hese hypothermia-related morbidities therefore have consequences reach
ing fare into the postoperative period. Prevention of inadvertent hypo
thermia is always indicated. Forced-air warming is the most effective
and safest method to prevent perioperative hypothermia.