Incidental appendectomy is frequently performed during nephrectomy for
Wilms' tumor. The rationale for this approach is that the onset of ap
pendicitis during a period of neutropenia after chemotherapy may cause
increased morbidity. Additionally, children receiving chemotherapy or
radiation therapy, or both, may experience abdominal pain, producing
a diagnostic dilemma if the appendix is still present. We reviewed the
charts of 1,910 children enrolled in the Third National Wilms' Tumor
Study who underwent primary nephrectomy. Four hundred and fifty-five p
atients (23.8 percent) had appendectomy at the time of nephrectomy. An
inversion appendectomy was performed upon 188 patients, and the appen
dix was excised in 267. Infectious complications and postoperative int
estinal obstructions occurred with equal frequency in children who did
or did not undergo appendectomy. The median follow-up period for the
entire group of patients was 5.1 years. Only three of the 1,455 childr
en (0.2 percent) who did not have an incidental appendectomy had appen
dicitis at two, seven and ten months after nephrectomy. None of the th
ree children experienced any perioperative morbidity after appendectom
y. These data suggest that incidental removal of the appendix is not e
ssential for children undergoing removal of a Wilms' tumor.