PROGNOSTIC VALUE OF HISTOPATHOLOGICAL PARAMETERS IN 51 SUPRAGLOTTIC SQUAMOUS-CELL CARCINOMAS

The prognosis for supraglottic squamous cell carcinomas is difficult t o establish. A study of 19 histopathological parameters 114 from the p rimary tumor and 5 from the lymph node metastases) was undertaken in 5 1 supraglottic epidermoid carcinomas. All patients were subjected to s upraglottic horizontal laryngectomy with bilateral functional neck dis section and postoperative radiotherapy. A discriminant analysis was pe rformed to relate the different histopathological variables to 5-year survival. Capsule rupture and the number of metastatic lymph nodes wer e the only two parameters significantly related to survival (P<.01). H istopathology (in particular, lymph node metastases) proved more effec tive in predicting patient evolution than TNM staging.