INCREASED LEVELS OF NGF IN SERA OF SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS

Authors
BRACCILAUDIERO L ALOE L LEVIMONTALCINI R GALEAZZI M SCHILTER D SCULLY JL OTTEN U
Citation
L. Braccilaudiero et al., INCREASED LEVELS OF NGF IN SERA OF SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS, NeuroReport, 4(5), 1993, pp. 563-565
Citations number
25
Categorie Soggetti
Neurosciences
Journal title
NeuroReport → ACNP
ISSN journal
09594965
Volume
4
Issue
5
Year of publication
1993
Pages
563 - 565
Database
ISI
SICI code
0959-4965(1993)4:5<563:ILONIS>2.0.ZU;2-#
Abstract
USING a specific enzyme-linked immunosorbent assay (ELISA) for human n erve growth factor (NGF), serum levels in patients with systemic lupus erythematosus (SLE) were measured. We found a consistent increase in NGF levels in SLE patients compared with controls. A good correlation exists between serum NGF level and severity of clinical manifestation. We hypothesize that NGF might play a role in the pathogenesis of auto immune disorders such as SLE.