REGULATION OF THE EUKARYOTIC PROTEIN-SYNTHESIS BY PHOSPHORYLATION OF ELONGATION FACTOR-II

Authors
ERDOGDU G CIRAKOGLU B KAN B
Citation
G. Erdogdu et al., REGULATION OF THE EUKARYOTIC PROTEIN-SYNTHESIS BY PHOSPHORYLATION OF ELONGATION FACTOR-II, Biochemical archives, 9(2), 1993, pp. 91-99
Citations number
26
Categorie Soggetti
Biology
Journal title
Biochemical archives → ACNP
ISSN journal
07495331
Volume
9
Issue
2
Year of publication
1993
Pages
91 - 99
Database
ISI
SICI code
0749-5331(1993)9:2<91:ROTEPB>2.0.ZU;2-G
Abstract
The phosphorylation of elongation factor 2 (EF-2) by Ca2+/calmodulin k inase III decreases its activity and results in inhibition of translat ion. The effects of different experimental conditions on the phosphory lation of EF-2 in rabbit reticulocyte have been investigated. The phos phorylation of EF-2 was enhanced in the presence of GDP and inhibited by cyclic-AMP and NEM whereas the ADP-ribosylation of EF-2 did not cha nge the extent of its phosphorylation.