BROAD-SPECTRUM MOBIUS SYNDROME ASSOCIATED WITH A 1-11 CHROMOSOME-TRANSLOCATION

The authors report a case of Mobius syndrome with Poland syndrome, cle ft palate, dextrocardia, mandibular hypoplasia, and multiple areas of diffuse brain volume loss. Karyotype demonstrated a t(1;11)(p22;p13) t ranslocation in the patient and his phenotypically normal father and b rother. This case extends the spectrum of congenital disorders that ar e associated with Mobius syndrome and raises the possibility of geneti c heterogeneity for the Mobius disorder.