Black sheep skins available in South India are affected by a defect ca
used by hyperpigmentation. The defect greatly devaluates skin and leat
her quality. Correlation between hyperpigmentation and certain physiol
ogical factors in sheep showed that there was increased epidermal pigm
entation and tyrosinase activity in the affected area of the skin. Ser
um albumin levels were decreased and globulin levels slightly increase
d. There was no variation in the levels of free amino acids in the ser
um. Plasma levels of iron, copper and zinc were not influenced by the
defect. Vitamin A, beta-carotene, nicotinic acid, and pantothenic acid
levels in serum showed slight decreases in affected animals. From the
results it is difficult to conclude that any one of the factors was s
olely responsible for the defect. A combined action may be responsible
.