Sm. Macrury et al., A COMPARISON OF DIFFERENT METHODS OF ASSESSING FREE-RADICAL ACTIVITY IN TYPE-2 DIABETES AND PERIPHERAL VASCULAR-DISEASE, Diabetic medicine, 10(4), 1993, pp. 331-335
Citations number
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Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
Increased free radical activity in diabetes mellitus may contribute to
the higher prevalence and mortality from macrovascular disease in dia
betic patients. To investigate this, levels of plasma antioxidants (su
peroxide dismutase, caeruloplasmin, plasma, and lysate thiol), diene c
onjugates, lipid peroxides, and chemiluminescence were measured in dia
betic and non-diabetic patients with peripheral vascular disease compa
red with healthy control subjects. Caeruloplasmin, diene conjugate rat
io, and lipid peroxides were significantly increased in patients with
vascular disease but there was no difference between diabetic and non-
diabetic patients. Conjugated diene ratio correlated with caeruloplasm
in (r = 0.40, p < 0.02) and inversely with superoxide dismutase level
(r = -0.36, p < 0.05) but there was no significant correlation between
other antioxidants and diene conjugates, lipid peroxides or chemilumi
nescence. The relationship between different indirect measurements of
free radical activity is variable but there appears to be no additive
effect of diabetes on the increased free radical activity associated w
ith vascular disease.