THE EFFECT OF ACARBOSE ON BLOOD-GLUCOSE PROFILES OF TYPE-2 DIABETIC-PATIENTS RECEIVING INSULIN THERAPY

Nine patients with Type 2 diabetes receiving insulin therapy were trea ted with acarbose 100 mg thrice daily for 1 week to investigate the ef fect of acarbose on blood glucose control. Daily blood glucose profile s contained fewer excursions during acarbose administration and low le vels were maintained. The M-value, an indicator of blood glucose fluct uation, decreased significantly from a run-in period value of 37.6 +/- 8.7 (SEM) to 16.7 +/- 4.0 during the acarbose period (p < 0.05) and r ose again to 28.9 +/- 6.7 (p greater-than-or-equal-to 0.05) in the fol low-up period. The 24-h urinary glucose excretion similarly decreased during acarbose administration. As expected, no decrease in HbA1C was observed due to the short treatment period. The 24-h urinary C-peptide excretions and serum lipids were not influenced by acarbose therapy. Frequent episodes of clinical hypoglycaemia were experienced while on acarbose therapy, indicating a decrease in insulin requirements. Adver se events such as flatulence and abdominal distention were observed in six out of nine cases. Symptoms were generally mild and well tolerate d, only one patient dropped out because of diarrhoea and abdominal pai n. We conclude that acarbose could usefully be administered to Type 2 diabetic patients treated with insulin to improve blood glucose contro l and reduce insulin requirement if the appropriate selection criteria were met.