PREPARATION AND PHARMACOLOGICAL EVALUATION OF ENANTIOMERS OF CERTAIN NONOXYGENATED APORPHINES - (- AND (-)-APORPHINE AND (+)- AND (-)-10-METHYLAPORPHINE())

The subject compounds were prepared as a part of a continuing structur e-activity study of the contrasting actions (agonism-antagonism) of ()- and (-)-11-hydroxy-10-methylaporphine at serotonin (5-HT1A) recepto rs. None of the targeted nonoxygenated aporphine derivatives demonstra ted significant activity in assays for any effects at serotonin 5-HT1A receptors. It is concluded that, in the aporphine series, serotonergi c agonist or antagonism requires an alkyl group ortho to a phenolic OH group in the A ring.