THE IMPORTANCE OF HYDROPHOBICITY IN THE MUTAGENICITY OF METHANESULFONIC-ACID ESTERS WITH SALMONELLA-TYPHIMURIUM TA100

Authors
DEBNATH AK HANSCH C
Citation
Ak. Debnath et C. Hansch, THE IMPORTANCE OF HYDROPHOBICITY IN THE MUTAGENICITY OF METHANESULFONIC-ACID ESTERS WITH SALMONELLA-TYPHIMURIUM TA100, Chemical research in toxicology, 6(3), 1993, pp. 310-312
Citations number
16
Categorie Soggetti
Toxicology,Chemistry
Journal title
Chemical research in toxicology → ACNP
ISSN journal
0893228X
Volume
6
Issue
3
Year of publication
1993
Pages
310 - 312
Database
ISI
SICI code
0893-228X(1993)6:3<310:TIOHIT>2.0.ZU;2-1
Abstract
The analysis of the mutagenic activity of a series of 15 methanesulfon ate esters with Salmonella typhimurium TA100 shows that it can be corr elated with the following equation: log TA100 = 1.10 log P + 0.73 log MMI - 2.53, where MMI is the relative rate of reaction of the esters w ith N-methyl-2-mercaptoimidazole and P is the octanol/water partition coefficient. The results are compared with a number of other structure -activity studies on mutagenesis by a variety of types of chemicals.