V. Nikolopoulou et al., LYMPHOCYTES FROM PATIENTS WITH CHRONIC DUODENAL-ULCER DISEASE SHOW ENHANCED PROLIFERATIVE RESPONSE TO BETA-ENDORPHIN, Hepato-gastroenterology, 40(2), 1993, pp. 116-119
We investigated the effect of phytohemagglutinin and the neuropeptide
beta-endorphin on the in vitro lymphocyte proliferative response in pa
tients with chronic ulcer disease and upper gastrointestinal bleeding
or in remission, acute ulcer or hemorrhagic gastritis, and in healthy
persons without upper gastrointestinal disease. We found that the addi
tion of beta-endorphin produced a strongly enhanced proliferative resp
onse to phytohemagglutinin in lymphocytes from patients with chronic u
lcer disease, and in particular from those with recent bleeding.