DYSPEPSIA AND DYSPEPSIA SUBGROUPS IN JAPAN - SYMPTOM PROFILES AND EXPERIENCE WITH CISAPRIDE

In 240 patients with symptoms of dyspepsia, recruited consecutively an d investigated in 12 hospitals in Japan, 24.2% were diagnosed having o rganic dyspepsia; 75.8% had functional dyspepsia, of whom 63.2% were d iagnosed by the investigator having dysmotility-like, 13.7% ulcer-like , 11.5% reflux-like, and 11.5% non-specific dyspepsia. There was, howe ver, considerable overlap of symptom profiles. Cisapride therapy initi ated in functional dyspeptic patients resulted in moderate or marked i mprovement in 79.1% of the patients with the highest response rates fo r dysmotility-like (85.2%), reflux-like (81.0%), and non-specific dysp epsia (76.1%) (versus 52.0% for ulcer-like dyspepsia).