S. Hosoda et al., EFFECT OF (S)-ALPHA-FLUOROMETHYLHISTIDINE AND SMS 201-995 ON GROWTH OF HISTAMINE-PRODUCING GASTRIC CARCINOID OF MASTOMYS-NATALENSIS, Agents and actions, 38, 1993, pp. 158-160
(S)-alpha-fluoromethylhistidine (FMH) administered by either i. p. inj
ection or continuous s. c. infusion leads to marked depletion of hista
mine levels in urine of Mastomys bearing transplantable histamine-prod
ucing argyrophilic gastric carcinoid. The continuous s.c. injection of
FMH appears to be superior to i.p. injection for suppressing HDC acti
vity in carcinoid cells. FMH administered by either route, however, do
es not appear to retard the growth of this tumour strain. Among 10 Mas
tomys receiving daily s. c. injection of SMS (500 mug/kg), only 2 Mast
omys's tumours regressed during treatment, but after termination of SM
S, they grew again. In the s. c. infusion groups administered with 200
and 400 mug of SMS, a definite effect of SMS on the tumour growth cou
ld not be obtained.