Pm. Shah et al., THE EFFECT OF SULFASALAZINE AND ITS METABOLITES ON HISTAMINE-RELEASE FROM HUMAN COLONIC AND GASTRIC MAST-CELLS, Agents and actions, 38, 1993, pp. 194-196
Mast cells isolated from human colon and stomach released histamine on
challenge with anti-human IgE. Sulphasalazine (1 nM - 100 muM) had no
effect on the secretion induced by optimal concentration of anti-IgE
but potentiated the release evoked by sub-maximal amounts of the ligan
d. Over the same concentration range, sulphapyridine had no effect on
the release. However, 5-aminosalicylic acid (5-ASA) produced a dose-de
pendent inhibition of secretion with an IC50 of ca 50 muM. These resul
ts are discussed in terms of the possible therapeutic action of sulpha
salazine.