THE EFFECT OF SULFASALAZINE AND ITS METABOLITES ON HISTAMINE-RELEASE FROM HUMAN COLONIC AND GASTRIC MAST-CELLS

Authors
SHAH PM BOULOS PB PEARCE FL
Citation
Pm. Shah et al., THE EFFECT OF SULFASALAZINE AND ITS METABOLITES ON HISTAMINE-RELEASE FROM HUMAN COLONIC AND GASTRIC MAST-CELLS, Agents and actions, 38, 1993, pp. 194-196
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Agents and actions → ACNP
ISSN journal
00654299
Volume
38
Year of publication
1993
Pages
194 - 196
Database
ISI
SICI code
0065-4299(1993)38:<194:TEOSAI>2.0.ZU;2-M
Abstract
Mast cells isolated from human colon and stomach released histamine on challenge with anti-human IgE. Sulphasalazine (1 nM - 100 muM) had no effect on the secretion induced by optimal concentration of anti-IgE but potentiated the release evoked by sub-maximal amounts of the ligan d. Over the same concentration range, sulphapyridine had no effect on the release. However, 5-aminosalicylic acid (5-ASA) produced a dose-de pendent inhibition of secretion with an IC50 of ca 50 muM. These resul ts are discussed in terms of the possible therapeutic action of sulpha salazine.