A mathematical model of the T-lymphocyte proliferation process (in viv
o and in vitro) is presented. This model takes into account cell-cycle
progression and the regulation by lymphokines (lymphocyte activating
factor interleukin 1 and T-cell growth factor interleukin 2). Using da
ta on the generalized picture of the short-term course of viral hepati
tis B, the parameter estimation procedure is carried out. The possibil
ity of immunocorrection (by means of injection of a pharmacologic dose
of IL-2) during the immune response to viral hepatitis B with T-lymph
ocyte deficiency is shown.