AUTOIMMUNE POLYENDOCRINE FAILURE - TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS AND HYPOTHYROIDISM - AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION IN A PATIENT WITH LYMPHOBLASTIC-LEUKEMIA

Authors
VIALETTES B MARANINCHI D SANMARCO MP BIRG F STOPPA AM MATTEIZEVACO C THIVOLET C HERMITTE L VAGUE P MERCIER P
Citation
B. Vialettes et al., AUTOIMMUNE POLYENDOCRINE FAILURE - TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS AND HYPOTHYROIDISM - AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION IN A PATIENT WITH LYMPHOBLASTIC-LEUKEMIA, Diabetologia, 36(6), 1993, pp. 541-546
Citations number
38
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
Journal title
Diabetologia → ACNP
ISSN journal
0012186X
Volume
36
Issue
6
Year of publication
1993
Pages
541 - 546
Database
ISI
SICI code
0012-186X(1993)36:6<541:APF-T(>2.0.ZU;2-A
Abstract
In this report we describe a patient who, after allogeneic bone marrow transplantation from her HLA-identical sister, developed polyendocrin e failure in the form of Type 1 (insulin-dependent) diabetes mellitus and hypothyroidism. This was the result of the transfer of donor lymph oid cells which were activated by allogeneic bone marrow transplantati on. The full chimerism of the recipient was demonstrated by restrictio n fragment length polymorphism analysis from nucleated blood cells and fibroblast DNA. During the 9-year follow-up, the donor developed hypo thyroidism and signs of pre-Type 1 diabetes. This clinical observation resembles the adoptive transfer of diabetes observed in non-obese-dia betic mice and BB rats and confirms the role of immune processes in th e pathogenesis of this disease.