AUTOIMMUNE POLYENDOCRINE FAILURE - TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS AND HYPOTHYROIDISM - AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION IN A PATIENT WITH LYMPHOBLASTIC-LEUKEMIA
B. Vialettes et al., AUTOIMMUNE POLYENDOCRINE FAILURE - TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS AND HYPOTHYROIDISM - AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION IN A PATIENT WITH LYMPHOBLASTIC-LEUKEMIA, Diabetologia, 36(6), 1993, pp. 541-546
Citations number
38
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
In this report we describe a patient who, after allogeneic bone marrow
transplantation from her HLA-identical sister, developed polyendocrin
e failure in the form of Type 1 (insulin-dependent) diabetes mellitus
and hypothyroidism. This was the result of the transfer of donor lymph
oid cells which were activated by allogeneic bone marrow transplantati
on. The full chimerism of the recipient was demonstrated by restrictio
n fragment length polymorphism analysis from nucleated blood cells and
fibroblast DNA. During the 9-year follow-up, the donor developed hypo
thyroidism and signs of pre-Type 1 diabetes. This clinical observation
resembles the adoptive transfer of diabetes observed in non-obese-dia
betic mice and BB rats and confirms the role of immune processes in th
e pathogenesis of this disease.