INCREASING PREVALENCE OF JUVENILE-ONSET TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS IN SARDINIA - THE MILITARY SERVICE APPROACH

In order to obtain new and more detailed information about temporal tr ends and geographic distribution of Type 1 (insulin-dependent) diabete s mellitus in Sardinia, we screened a series of birth cohorts (1936-19 73) of all male army conscripts aged 18-19 years, filed in the Sardini an Conscript Register where Type 1 diabetes is a cause of rejection. A total of 678 diabetic subjects, born and permanently residing in Sard inia, was identified. The point prevalence (x 1000) at the age of 20 y ears in the birth cohorts ranged from values close to zero for the fir st ten cohorts (1936-1945) up to a maximum of 3.08 (95 % confidence li mits 2.28-4.08) for the 1966 cohort and continued high thereafter alth ough an apparent decrease was observed from the early 1970s birth coho rts. Type 1 diabetes was distributed throughout the four provinces of Sardinia with no particularly significant heterogeneity; however, in a ccordance with the geographical distribution of diabetes cases of the Eurodiab Ace survey (1989-1990), the highest prevalence of the disease was observed in the Cagliari and Oristano provinces, followed by Nuor o and Sassari. These data suggest a gradually increasing trend of male Type 1 diabetes prevalence in Sardinia with a 29-fold increase betwee n the late 1930s and the late 1960s birth cohorts. This seems to confi rm the high incidence of Type 1 diabetes in the 0-14 and 0-29 year age groups recently reported among Sardinians during the Eurodiab Ace col laborative multicentre study.