SYNTHESIS AND BIOLOGICAL PROPERTIES OF NOVEL ANALOGS OF DELTA-SLEEP INDUCING PEPTIDE (DSIP) .1. ANTIEPILEPTIC ACTION

To study structure-functional relationship in the series of DSIP, elev en DSIP analogues varying in positions 1, 2 and 6 were synthesized by the solid-phase method using both Boc- and Fmoc-approaches. The antiep ileptic action of these analogues was compared with that of DSIP. The seizure activity was induced by the corazol or picrotoxin i. p. inject ion. Some analogues proved more efficient as antiepileptic agents than DSIP after their central (50 mug/kg in rats) and peripheral (1.0 mg/k g in mice) administration.