SUBCLASS-SPECIFIC SERUM ANTIBODY-RESPONSES TO RECOMBINANT NORWALK VIRUS CAPSID ANTIGEN (RNV) IN ADULTS INFECTED WITH NORWALK, SNOW MOUNTAIN, OR HAWAII VIRUS

Subclass-specific antibody responses to the Norwalk virus capsid prote in in adults challenged with Norwalk, Snow Mountain, or Hawaii virus w ere evaluated by solid-phase enzyme immunoassay using recombinant Norw alk virus capsid antigen (rNV). Fourfold or greater serum immunoglobul in G (IgG) antibody responses to rNV were detected in 15 of 20 volunte ers challenged with Norwalk virus, and serum IgA and IgM antibody resp onses to rNV were seen in almost all subjects who had rNV IgG response s. Serum rNV IgG antibody responses also were detected in 6 of 15 volu nteers challenged with Snow Mountain virus and 2 of 12 volunteers chal lenged with the Hawaii virus. However, the magnitude of antibody respo nse and the geometric mean postchallenge rNV IgG antibody titers were lower in subjects challenged with Snow Mountain or Hawaii virus, and s erum IgA and IgM responses generally did not occur.