INVASIVE ASPERGILLOSIS IN LEUKEMIC CHILDREN

Two cases of invasive aspergillosis are reported. Case 1, a 3-year-old boy with leukemic transformation of myelodysplastic syndrome, had an aspergillous infection in the hand, resulting in necrosis of the thumb . Case 2, an 18-year-old girl with acute megakaryoblastic leukemia, ha d an aspergillus skin infection on the wrist, accompanied by swelling and discoloration of the arm. In Cast 2, angiography revealed a hypova scular lesion and vascular irregularity, suggesting that vessels were involved. Intra-arterial infusion of urokinase and amphotericin B led to improvement of these symptoms in this patient. The combination of u rokinase and an antifungal drug should be considered for intractable a spergillus infections involving the extremities.