DETERMINATION OF COLLISION-INDUCED DISSOCIATION MECHANISMS AND CROSS-SECTIONS IN ORGANOPHOSPHORUS COMPOUNDS BY ATMOSPHERIC-PRESSURE IONIZATION TANDEM MASS-SPECTROMETRY

Citation
Cs. Harden et al., DETERMINATION OF COLLISION-INDUCED DISSOCIATION MECHANISMS AND CROSS-SECTIONS IN ORGANOPHOSPHORUS COMPOUNDS BY ATMOSPHERIC-PRESSURE IONIZATION TANDEM MASS-SPECTROMETRY, Organic mass spectrometry, 28(5), 1993, pp. 585-592
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear",Spectroscopy
Journal title
ISSN journal
0030493X
Volume
28
Issue
5
Year of publication
1993
Pages
585 - 592
Database
ISI
SICI code
0030-493X(1993)28:5<585:DOCDMA>2.0.ZU;2-8
Abstract
Nineteen organophosphorus compounds (OPCs) of the generic classes (dia lkyl alkyl'-phosphonates (twelve compounds) and tri-alkyl phosphates ( seven compounds) were investigated by atmospheric pressure ionization (API) tandem mass spectrometry (MS/MS). All OPCs showed consistent and comparable collision-induced dissociation (CID) pathways allowing for a generalized scheme for dissociation. When the alkyl groups are equa l to or larger than ethyl, CID mechanisms are dominated by McLafferty rearrangements and neutral losses are stable molecules in all cases ex cept cleavage of P-C or O-C bonds to form alkyl fragment ions. CID cro ss-sections for the OPCs were determined with excellent reproducibilit y and a good correlation was found with a simple model. Inferences wit h respect to ionic structures were made from observed trends in the cr oss-section measurements. Limitations in API-MS/MS instruments of this design are found in the energy distribution of the ionization and ion sampling events.