Mr. Kilbourn et al., INVIVO IMAGING OF VESICULAR MONOAMINE TRANSPORTERS IN HUMAN BRAIN USING [C-11] TETRABENAZINE AND POSITRON EMISSION TOMOGRAPHY, Journal of neurochemistry, 60(6), 1993, pp. 2315-2318
The pharmacokinetics of [C-11]tetrabenazine, a high-affinity radioliga
nd for the monoamine vesicular transporter, were determined in living
human brain using in vivo imaging by positron emission tomography (PET
). The radiotracer showed high brain uptake and rapid washout from all
brain regions with relatively slower clearance from regions of highes
t concentrations of monoamine vesicular transporters (striatum), resul
ting in clear differential visualization of these structures at short
intervals after injection (10-20 min). As the first human PET imaging
study of a vesicular neurotransmitter transporter, these experiments d
emonstrate that external imaging of vesicular transporters forms a new
and valuable approach to the in vivo quantification of monoaminergic
neurons, with potential application to the in vivo study of neurodegen
erative disorders such as Parkinson's disease.