Mj. Wayner et al., ETHANOL AND DIAZEPAM INHIBITION OF HIPPOCAMPAL LTP IS MEDIATED BY ANGIOTENSIN-II AND AT(1) RECEPTORS, Peptides, 14(3), 1993, pp. 441-444
Angiotensin II (AII) inhibits the induction of hippocampal long-term p
otentiation (LTP), a frequency-dependent model of learning and memory.
These results demonstrate that the dose-dependent inhibition of LTP d
ue to ethanol (EtOH) and diazepam (DZ) involves AII. Inhibition of LTP
induction by All, EtOH, and DZ can be blocked by All receptor antagon
ists saralasin and lorsartan (DuP 753). Lorsartan is a competitive ant
agonist of the AT1 subtype All receptor. Therefore, the EtOH and DZ in
hibition of LTP induction is mediated by AT1 receptors. These results
indicate a new role for AII in the brain in the possible mediation of
memory deficits associated with alcohol and the benzodiazepines.