CAUSAL STUDY OF ISOLATED ULNAR-FIBULAR DEFICIENCY IN HUNGARY, 1975-1984

A population-based and validated data set of 114 cases with isolated u lnar-fibular deficiency was evaluated in Hungary, 1975-1984. Ulnar-fib ular type had the third most common birth prevalence (0.07 per 1000) a mong isolated congenital limb deficiency types. This type is relativel y rarely associated with nonlimb defects, a single limb is affected in two-thirds of cases, nearly all other cases had femur-fibula-ulna (FF U) dysostosis. Upper and lower limbs, right and left sides, are equall y affected, however, there is an obvious male excess (71%). Case-contr ol analysis indicated a lower birth weight due to intrauterine growth retardation, higher birth order, lower socioeconomic status of parents , and a more frequent reported subfertility. The family study identifi ed one familial cluster (one siboccurrence) among 331 first-degree rel atives.