EFFECT OF DOMPERIDONE-INDUCED HYPERPROLACTINEMIA ON THE ACTIVITY OF SOME LYSOSOMAL-ENZYMES IN PERIPHERAL POLYMORPHONUCLEAR LEUKOCYTES OF HEALTHY WOMEN

Pharmacologically induced hyperprolactinemia in healthy volunteers was shown to result in an increased metabolic burst of polymorphonuclear leukocytes (PMNLs) stimulated by opsonized zymosan and phorbol myrista te acetate. Simultaneously increased superoxide production was observe d both in stimulated and resting PMNLs, together with enhanced extrace llular release of lysozyme and myeloperoxidase. The results indicate t hat pharmacologically induced hyperprolactinemia could provide a model for studying the immunomodulatory effects of prolactin (PRL) on the f unctions and mechanisms of nonspecific immunity. Additional evidence f or the involvement of PRL in controlling mechanisms of phagocytosis, w as found which deserves further attention as they play an important ro le in promoting the defence capacity of the body.