DIRECT INFLUENCE OF MORPHINE ON THE RELEASE OF ARACHIDONIC-ACID AND ITS METABOLITES

Authors
SERGEEVA MG TERENTJEVA IV MEVKH AT VARFOLOMEEV SD
Citation
Mg. Sergeeva et al., DIRECT INFLUENCE OF MORPHINE ON THE RELEASE OF ARACHIDONIC-ACID AND ITS METABOLITES, FEBS letters, 323(1-2), 1993, pp. 163-165
Citations number
21
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
323
Issue
1-2
Year of publication
1993
Pages
163 - 165
Database
ISI
SICI code
0014-5793(1993)323:1-2<163:DIOMOT>2.0.ZU;2-5
Abstract
The influence of 10(-10)-10(-6) M morphine on the release of [H-3]arac hidonic acid and its metabolites ([H-3]AAM) from prelabeled resident p eritoneal murine macrophages was investigated. Morphine enhanced [H-3] AAM release from A23187- and LPS-stimulated macrophages, as well as th e basal release of [H-3]AAM. Dose-response curves showed a maximum at 10(-8) M morphine. Naloxone had no effect on morphine enhancement of [ H-3]AAM release. These results are in agreement with the hypothesis th at [H-3]AAM may be involved in the effects of morphine.