GLOMERULAR-FILTRATION RATES IN PERSONS EVALUATED AS LIVING-RELATED DONORS - ARE OUR STANDARDS TOO HIGH

We have retrospectively analyzed the glomerular filtration rate by -I- 125 iothalamate clearance and creatinine clearance in a group of 661 p ersons evaluated as potential kidney donors. The average GFR in this p opulation is lower than that reported in previous studies and ranges f rom 102+/-15 and 114+/-17 ml/min for males and females age 21-30 to 84 +/-13 and 79+/-15 ml/min for males and females age 51-60. Furthermore, there has been a gradual decrease in GFR in this population from 1970 to 1990 in both the entire population and in those under the age of 4 0. The cause of this drop is not apparent. These data can be utilized to determine the appropriateness of a potential donor for donation, an d may indicate that our current standards are too high.