BACTERIAL ADHERENCE AND EPITHELIAL-CELL CYTOKINE PRODUCTION

Authors
SVANBORG C AGACE W HEDGES S LINDER H SVENSSON M
Citation
C. Svanborg et al., BACTERIAL ADHERENCE AND EPITHELIAL-CELL CYTOKINE PRODUCTION, Zentralblatt fur Bakteriologie, 278(2-3), 1993, pp. 359-364
Citations number
19
Categorie Soggetti
Microbiology,Virology
Journal title
Zentralblatt fur Bakteriologie → ACNP
ISSN journal
09348840
Volume
278
Issue
2-3
Year of publication
1993
Pages
359 - 364
Database
ISI
SICI code
0934-8840(1993)278:2-3<359:BAAECP>2.0.ZU;2-N
Abstract
Epithelial cell lines produce the cytokines IL-1alpha, IL-6 and IL-8 w hen stimulated with Escherichia coli. The cytokine response is enhance d by P fimbriae. The epithelial cell lines also respond to stimulation with other cytokines. These in vitro findings were confirmed in vivo in patients with E. coli infection who secreted IL-6 and IL-8 into the urine. The observations suggest that epithelial cells play a more act ive role in the mucosal immune response than previously recognized.