The first three well-documented cases of pure, extraskeletal telangiec
tatic osteosarcoma of the soft tissues are presented in this article.
The distinctive gross features were a predominance of large, blood-fil
led spaces, which, on histologic examination, were large blood-filled
cavities in association with cyst-like walls containing anaplastic spi
ndle cells and definite osteoid production in two of three cases. One
of the cases is of additional clinical interest because the teen-aged
daughter of the woman patient had died 1 year previously of a high-gra
de intramedullary osteosarcoma of bone.