Refinement of optimal neonatal intensive care for the very pre-term in
fants with risk of developing neonatal complications including retinop
athy of prematurity (ROP) has been under development since the late 19
80's. During the last,decade better methods for supporting the respira
tion including surfactant treatment has contributed to the increased s
urvival rate which today is more than 50% for infants born between 24
and 28 completed weeks of gestation. Improvement in the 'environmental
engineering' in the neonatal intensive care unit is necessary to impr
ove the longterm outcome regarding disabilities and handicaps includin
g ROP. Clinical research in neonatology clearly shows that a high qual
ity medical and nursing care is required for these infants.