INVITRO PERMEABILITY TO SALICYLIC-ACID OF HUMAN, RODENT, AND SHED SNAKE SKIN

In-vitro permeability to salicylic acid of human, rodent, and shed sna ke skin has been examined for the purpose of selecting model membranes for human skin corresponding to different anatomic sites, since a mar ked regional variation is suggested among the different sites. The gre atest permeability to salicylic acid was observed in the scrotum, that of the sole was negligible. The cheek, neck, and inguinal skin seemed more permeable than the breast, back, thigh, lower leg, or foot skin. Shed snake and skin of hairless rat were found to show similar permea bility to human breast and thigh skin. Wistar rat and nude mouse skin showed similar permeability to human cheek, neck, and inguinal skin.