LIGHT-STABILITY OF MOLSIDOMINE IN INFUSION FLUIDS

The influence of artificial light, daylight or stimulated sunlight on the stability of molsidomine was investigated. In static experiments a n 80 mug mL-1 solution of molsidomine in saline was stored in an unpro tected infusion bag. During dynamic experiments the molsidomine soluti on (80 mug mL-1) was dropped at 12.5 mL h-1 from an unprotected infusi on bag, from an infusion bag covered with aluminium-foil. or from an i nfusion bag protected with a UV-cover. Either unprotected infusion tub ing or infusion tubing with a UV-filter were connected to the infusion bags. Static as well as dynamic experiments showed a half-life of abo ut 20 min for the unprotected molsidomine solutions, when placed behin d a window during a sunny day. Protection from light of the infusion b ag but not of the infusion tubing had only a minor influence on the dr ug half-life. Protection of the infusion bag and the infusion tubing w ith a UV-filter increased the half-life to several days. These results confirm that both the infusion bag and the infusion tubing need adequ ate light protection during molsidomine administration.