The efficacy of bronchodilator nebuliser solutions may be influenced b
y the presence of preservatives. In a double blind, randomised, crosso
ver study the effect of preservatives in determining the airway respon
ses to 5 mg of terbutaline was studied in a group of 21 atopic asthmat
ic patients. The presence of preservatives affected neither the bronch
odilator action of terbutaline nor its protection against bronchoconst
riction induced by histamine.