ENKEPHALIN ANTISENSE PEPTIDES - DESIGN, SYNTHESIS, AND BIOLOGICAL-ACTIVITY

Authors
MISRA PK HAQ W KATTI SB MATHUR KB RAGHUBIR R PATNAIK GK DHAWAN BN
Citation
Pk. Misra et al., ENKEPHALIN ANTISENSE PEPTIDES - DESIGN, SYNTHESIS, AND BIOLOGICAL-ACTIVITY, Pharmaceutical research, 10(5), 1993, pp. 660-661
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Pharmaceutical research → ACNP
ISSN journal
07248741
Volume
10
Issue
5
Year of publication
1993
Pages
660 - 661
Database
ISI
SICI code
0724-8741(1993)10:5<660:EAP-DS>2.0.ZU;2-4
Abstract
The antisense mRNA complementary to the sense strand of Met-enkephalin encodes the antisense peptides, His-Glu-Ala-Pro-Ile (compound 88/62). The antisense peptide and its (Gln1)-analogue (compound 88/63) have s ynergestic effects on the opioid activity of Met-enkephalin in the GPI test system.