Lp. Grande et al., EFFECT OF A NEW FORMULATION OF ALMAGATE ON GASTROESOPHAGEAL REFLUX INPATIENTS WITH ESOPHAGITIS - RANDOMIZED, SINGLE-BLIND, CROSS-OVER STUDY, Revista espanola de enfermedades digestivas, 83(4), 1993, pp. 229-234
The effect of postprandial administration of a new formulation of alma
gate (1,5 g, po) or an association of alginate+antiacid (2,4 g, po) on
gastric alkalinization and gastroesophageal reflux were assessed in a
randomized, single-blind, cross-over study in 21 patients with gastro
esophageal reflux disease. Continuous intragastric and esophageal acid
ity was evaluated by postprandial intraluminal pHmetry. When comparing
both preparations, the new formulation of almagate significantly impr
oved all pHmetric variables (number of reflux episodes (3 vs 6, p = 0,
029), time of esophageal exposition to pH < 4,0 (1 vs 9 minutes, p = 0
,009), duration of longest reflux episode (1 vs 3 minutes, p = 0,036),
reflux index (1 vs 2, p = 0,047), and intragastric time with pH great
er than 4,0 (108 vs 46 minutes, p = 0,003). This results suggest that
the new formulation of almagate could be effective in the treatment of
gastroesophageal reflux disease, since acidity profile of patients tr
eated with it have been shown an intragastric long-lasting alkalinizat
ion wave.