CONSTITUENTS OF CIMICIFUGAE RHIZOMA .1. ISOLATION AND CHARACTERIZATION OF 10 NEW CYCLOARTENOL TRITERPENES FROM CIMICIFUGA-HERACLEIFOLIA KOMAROV

Ten new highly oxidized cycloartane-type triterpenoids, 24-epi-7,8-did ehydrocimigenol, 7,8-didehydrocimigenol, 25-O-acetyl-7,8-didehydrocimi genol, 3-keto-24-epi-7,8-didehydrocimigenol, diacetyl-24-epi-7,8-dideh ydrocimigenol-3-xyloside, O-acetyl-24-epi-7,8-didehydrocimigenol-3-xyl oside, 24-epi-7,8-didehydrocimigenol-3-xyloside, 8-didehydro-24-O-acet ylhydroshengmanol-3-xyloside, 24-epi-acerinol and heracleifolinol, wer e isolated from the rhizome of Cimicifuga heracleifolia KOMAROV and th eir structures were determined by the use of two-dimensional nuclear m agnetic resonance (2D NMR) techniques (H-1-H-1 correlation spectroscop y (COSY), H-1-C-13 COSY, H-1-C-13 long-range COSY) and by X-ray diffra ction analysis of the 3-keto compound.