PIPERIDINEACRYLATE DERIVATIVES AS POTENTIAL ANTIALLERGY AGENTS

Authors
SUGIYAMA M SAKAMOTO T KAMIGAKI Y FUKUMI H ITOH K SATOH Y YAMAGUCHI T
Citation
M. Sugiyama et al., PIPERIDINEACRYLATE DERIVATIVES AS POTENTIAL ANTIALLERGY AGENTS, Chemical and Pharmaceutical Bulletin, 41(5), 1993, pp. 882-888
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
41
Issue
5
Year of publication
1993
Pages
882 - 888
Database
ISI
SICI code
0009-2363(1993)41:5<882:PDAPAA>2.0.ZU;2-H
Abstract
A new series of piperidineacrylate derivatives was prepared and evalua ted for antiallergic activity. Most of the compounds showed potent act ivities in the rat passive cutaneous anaphylaxis (PCA) assay. In parti cular, ethyl s(4-fluorophenyl)methoxyethyl]4-piperidineacrylate (1a) w as more potent than oxatomide and terfenadine in this assay, and was s elected for further study. Some pharmacological properties of 1a are p resented.